Title of article
A general strategy for the synthesis of difluoromethyl-containing pyrazoles, pyridines and pyrimidines
Author/Authors
Viktor O. Iaroshenko، نويسنده , , Verena Specowius، نويسنده , , Katharina Vlach، نويسنده , , Marcelo Vilches-Herrera، نويسنده , , Dmytro Ostrovskyi، نويسنده , , Satenik Mkrtchyan، نويسنده , , Alexander Villinger، نويسنده , , Peter Langer، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
15
From page
5663
To page
5677
Abstract
Difluoromethyl-containing heteroannulated pyridines, pyrimidines and pyrazoles are prepared by a two step method. The regioselective cyclizations of electron-excessive aminoheterocycles, hydrazines and amidines with CF2Cl-substituted 1,3-dicarbonyl compounds provide the corresponding CF2Cl-substituted heterocycles. Subsequent radical reactions with trimethylstannane or allyltrimethylstannane gave difluoromethyl-containing heteroannulated pyridines, pyrimidines and pyrazoles, respectively.
Keywords
Cyclizations , organofluorine compounds , Regioselectivity , Purine isosteres , N-Heterocycles
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103482
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