Title of article
An expeditious approach to 1-(isoquinolin-1-yl)guanidines via a three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, with carbodiimide
Author/Authors
Huanhuan Wang، نويسنده , , Shengqing Ye، نويسنده , , Hanpeng Jin، نويسنده , , Jianping Liu، نويسنده , , Jie Wu، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
7
From page
5871
To page
5877
Abstract
A small library of 1-(isoquinolin-1-yl)guanidine is constructed efficiently via a silver triflate-catalyzed three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, with carbodiimide. The preliminary biological screens of these isoquinoline library members have been evaluated, which show promising results as PTP1B inhibitor and HCT-116 inhibitor.
Keywords
2-Alkynylbenzaldehyde , Carbodiimide , 1-(Isoquinolin-1-yl)guanidine , Sulfonohydrazide , silver triflate
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103506
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