An efficient one-pot method for the synthesis of novel ferrocene–triamide conjugates via pseudo five-component reaction

A simple and efficient one-pot synthesis of novel ferrocene–triamide conjugates from the reaction of ferrocenecarboxaldehyde with Meldrum’s acid and isocyanides in the presence of NH-containing compounds is described. This transformation proceeds through the creation of two Csingle bondC bonds, two Csingle bondN bonds, and one Cdouble bond; length as m-dashO bond, leading to three peptide bonds, and presumably occurs via a domino sequence involving Knoevenagel condensation, [1+4] cycloaddition, deacetonation, and aminolysis reactions.