Title of article
Highly enantioselective hydrogenation of 2-oxo-4-arybutanoic acids to 2-hydroxy-4-arylbutanoic acids
Author/Authors
Lufeng Zhu، نويسنده , , Houhe Chen، نويسنده , , Qinghua Meng، نويسنده , , Weizheng Fan، نويسنده , , Xiaomin Xie، نويسنده , , Zhaoguo Zhang، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
5
From page
6186
To page
6190
Abstract
The Ru-catalyzed asymmetric hydrogenation of 2-oxo-4-arybutanoic acids to afford 2-hydroxy-4-arybutanoic acids was accomplished by employing SunPhos as chiral ligand and 1 M aq HBr as additive. The high enantioselectivities (88.4%–92.6% ee) and efficiency (TON=10,000, TOF=300 h−1) make this method efficient for the synthesis of an important intermediate, (R)-2-hydroxy-4-phenylbutanoic acid, for ACE inhibitors.
Keywords
asymmetric hydrogenation , ?-Keto acid , Ruthenium , SunPhos , Additive
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103540
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