Title of article
Synthesis of nitrilotriacetic acid terminated tethers for the binding of His-tagged proteins to lipid bilayers and to gold
Author/Authors
Ammathnadu S. Achalkumar، نويسنده , , Richard J. Bushby، نويسنده , , Stephen D. Evans، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
6
From page
6246
To page
6251
Abstract
Nitrilotriacetic acid terminated tethers for trapping of His-tagged proteins have been synthesized and characterized. Compound 1, containing a lipophilic cholesterol anchor, hydrophilic oligoethoxy chain linker, and nitrilotriacetic acid terminus, can be used for attaching His-tagged proteins to phospholipid bilayers. Compound 2, containing a gold binding thioacetate anchor, hydrophilic oligoethoxy chain, and nitrilotriacetic acid terminus, can be used to tether His-tagged proteins to a gold surface.
Keywords
Cholesterol anchor , Supported bilayer membranes , His-tagged proteins , Nitrilotriacetic acid , Self-assembly
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103550
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