Title of article :
Biverlactones A–D, new circumventors of arbekacin resistance in MRSA, produced by Penicillium sp. FKI-4429
Author/Authors :
Masato Iwatsuki، نويسنده , , Toshiya Ishimori، نويسنده , , Tsuyoshi Yamamoto، نويسنده , , Keiko Takata، نويسنده , , Mihoko Mori، نويسنده , , Kenichi Nonaka، نويسنده , , Rokuro Masuma، نويسنده , , Yoichi Hayakawa، نويسنده , , Hideaki Hanaki، نويسنده , , Kazuro Shiomi، نويسنده , , Satoshi Omura، نويسنده ,
Abstract :
Biverlactones, new circumventors of arbekacin resistance in methicillin-resistant Staphylococcus aureus (MRSA) were isolated from a culture broth of Penicillium sp. FKI-4429. Their structures were elucidated by spectroscopic studies, including various NMR experiments. Biverlactones A–D had novel skeletons, consisting of a lactone ring conjugated with exo- or endo-olefin, a carboxylic group and a characteristic alkyl side chain in common.
