Title of article
Sporolide B: synthetic studies
Author/Authors
Jeffery A. Gladding، نويسنده , , James P. Bacci، نويسنده , , Scott A. Shaw، نويسنده , , Amos B. Smith III، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
10
From page
6697
To page
6706
Abstract
Studies directed toward the synthesis of the architecturally complex marine natural product sporolide B are described. Synthetic analysis suggested advanced hydroquinone and benzodiquinane fragments, which upon elaboration were successfully united via an ester linkage. Macrocyclization studies were then carried out, and although a novel macrocyclization product was obtained, subsequent studies revealed that the tertiary hydroxyls at C(6) and C(10) were too sterically encumbered to participate in a successful macrocyclization to furnish sporolide B.
Keywords
Sporolide , Natural products , Synthesis , Benzodiquinane , Hydroquinone
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103599
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