Author/Authors :
Ana T.P.C. Gomes، نويسنده , , Anna C. Cunha، نويسنده , , Maria do Ros?rio M. Domingues، نويسنده , , Maria G.P.M.S. Neves، نويسنده , , Augusto C. Tome، نويسنده , , Artur M.S. Silva، نويسنده , , Fernanda da C. Santos، نويسنده , , Maria C.B.V. Souza، نويسنده , , Vitor F. Ferreira، نويسنده , , José A.S. Cavaleiro، نويسنده ,
Abstract :
New porphyrin/4-quinolone conjugates were synthesized from the Suzuki–Miyaura coupling reaction of a β-borylated porphyrin with bromo-4-quinolones containing N-ethyl and N-d-ribofuranosyl substituents. The use of electrospray ionization tandem mass spectrometry showed important information about the fragmentation pathways of the new compounds. It was possible to distinguish between those compounds with the porphyrin moiety linked at the 6-position of the quinolone unit from their 7-substituted isomers. The new compounds showed to be good singlet oxygen generators.
Keywords :
photosensitizers , Porphyrin , Quinolones , Suzuki–Miyaura coupling , Singlet oxygen
