Author/Authors :
Yiyun Wang، نويسنده , , Ziyuan Li، نويسنده , , Yue Huang، نويسنده , , Changhua Tang، نويسنده , , Xiaoming Wu، نويسنده , , Jinyi Xu، نويسنده , , Hequan Yao، نويسنده ,
Abstract :
A mild copper(II)-catalyzed oxidation of 4-carboxythiazolines and 4-carboxyoxazolines to 4-carboxythiazoles and 4-carboxyoxazoles has been developed. Various substrates with alkyl or aryl substitutions at 2-position on azoline ring could be smoothly oxidized to the desired products in good to excellent yields. Moreover, the hydrolysis of the ester group could be avoided under this method.
Keywords :
Thiazole , Catalysis , Oxidation , copper , oxazole
