Title of article :
Solvent-Free, Efficient Synthesis of 2,5-Piperazinediones from BocProtected Dipeptide Esters under Microwave Irradiation
Author/Authors :
Avendano، Carmen نويسنده , , Sanchez، J. Domingo نويسنده , , Menendez، J. Carlos نويسنده , , Lopez-Cobenas، Alberto نويسنده , , Cledera، Pilar نويسنده , , Perez-Contreras، Rafael نويسنده , , Lopez-Alvarado، Pilar نويسنده , , Ramos، M. Teresa نويسنده ,
Abstract :
Microwave irradiation allows the efficient, solvent-free transformation of N-Boc dipeptide esters into 2,5-piperazinediones. The microwave-assisted conditions were found to be much better than traditional heating in terms of reaction time, yield and stereocenter integrity.
Keywords :
Dipeptides , microwave irradiation , Cyclizations , Heterocycles , diketopiperazines
