A simple method for synthesis of 5-CF3 substituted dienamides via rearrangement of 2H-pyran derivatives

A simple and novel method for synthesis of 5-trifluoromethyl 2,4-dienamides with up to 95% yield under mild condition was first reported. With α,α-dicyanoalkenes and trifluoromethylketones as starting materials, the vinylogous aldol reaction was introduced and then followed by rearrangement of the 2H-pyran intermediate.