Title of article
Synthesis of rodocaine
Author/Authors
Meng-Yang Chang، نويسنده , , Hang-Yi Tai، نويسنده , , Yeh-Long Chen، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
8
From page
7673
To page
7680
Abstract
A new method for synthesis of rodocaine (1) is presented. Two key steps were carried out by the N-bromosuccinimide (NBS)-mediated intermolecular addition of known enamine 5 with allyltrimethyl silane in presence of boron trifluoride etherate (BF3/OEt2) and the intramolecular ring-closing metathesis of triene 3. The Diels–Alder cycloaddition of triene 3 with different ethyl propiolates was also studied.
Keywords
Ring-closing metathesis , Deconjugation , Diels–Alder cycloaddition , Wittig olefination , Octahydropyrindine , Rodocaine
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103708
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