Title of article
The enantioselective synthesis of tetracyclic methyllycaconitine analogues
Author/Authors
J. Kevin Sparrow، نويسنده , , David Barker، نويسنده , , Margaret A. Brimble، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
11
From page
7989
To page
7999
Abstract
A new enantioselective synthesis of ABEF ring analogues of methyllycaconitine has been developed using a chiral cobalt(III) salen-catalyzed Diels–Alder reaction to form the B ring. Subsequent elaboration to form the A, E and F rings was achieved by sequential Dieckmann, Mannich and Wacker-type cyclizations to afford tetracyclic analogues in 97.5% ee.
Keywords
Methyllycaconitine , Enantioselective , Diels–Alder reaction , Semi-synthesis , Cobalt(III) salen catalyst
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103746
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