Author/Authors :
Han-Feng Cui، نويسنده , , Lian Wang، نويسنده , , Lijun Yang، نويسنده , , Jing Nie، نويسنده , , Yan Zheng، نويسنده , , Jun-An Ma، نويسنده ,
Abstract :
An efficient and direct aldol-type condensation of ethyl diazoacetate with trifluoromethyl ketones was developed in the presence of dialkyl zinc. A series of trifluoromethylated products were obtained in good to excellent yields (60–95%). A preliminary extension to a catalytic enantioselective aldol reaction of ethyl diazoacetate to trifluoromethyl ketones (up to 72% ee) is also described.
Keywords :
Aldol condensation , Enantioselectivity , Ethyl diazoacetate , Trifluoromethyl ketone
