Title of article
Acid-induced conformational alteration of cis-preferential aromatic amides bearing N-methyl-N-(2-pyridyl) moiety
Author/Authors
Iwao Okamoto، نويسنده , , Masayuki Terashima، نويسنده , , Hyuma Masu، نويسنده , , Mayumi Nabeta، نويسنده , , Kaori Ono، نويسنده , , Nobuyoshi Morita، نويسنده , , Kosuke Katagiri، نويسنده , , Isao Azumaya، نويسنده , , Osamu Tamura، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
8
From page
8536
To page
8543
Abstract
A series of cis-preferential aromatic N-methyl amides was designed and synthesized, and acid-induced conformational alteration of these compounds was investigated by means of NMR measurements in solution and X-ray crystal structure analysis. Compounds with a terminal N-methyl-N-(2-pyridyl) amide unit showed acid-induced conformational change from cis to trans, while those with a terminal N-methyl-2-pyridinecarboxamide unit showed a change of the carbonyl orientation from anti to syn with retention of cis conformation.
Keywords
Pyridine , foldamer , Molecular switch , Hydrogen bond , External stimulus responsive
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103816
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