Title of article
Reaction of 2-chloroindole-3-carbaldehyde with epihalogenohydrins. Tandem oxirane-opening—1,3-oxazole-closure process
Author/Authors
Konstantin F. Suzdalev، نويسنده , , Sophia V. Den’kina، نويسنده , , Gennadii S. Borodkin، نويسنده , , Valerii V. Tkachev، نويسنده , , Mikhail A. Kiskin، نويسنده , , Mikhail E. Kletsky، نويسنده , , Oleg N. Burov، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
5
From page
8775
To page
8779
Abstract
Reaction of 2-chloroindole-3-carbaldehyde with epibromohydrin gives the expected 1-(oxiran-2-ylmethyl) derivative. However the analogous reaction with epichlorohydrin leads to the formation of the oxazolo[3,2-a]indole skeleton. Some chemical properties of this tricyclic system were investigated. Its reaction with secondary amines unexpectedly proceeds with the opening of the oxazole ring.
Keywords
Indoles , Aldehydes , Epihalogenohydrins , 2-a]indole
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103848
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