• Title of article

    Chemistry of renieramycins. Part 11: Total synthesis of (±)-cribrostatin 4

  • Author/Authors

    Masashi Yokoya، نويسنده , , Hiroshi Ito، نويسنده , , Naoki Saito، نويسنده ,

  • Issue Information
    هفته نامه با شماره پیاپی سال 2011
  • Pages
    8
  • From page
    9185
  • To page
    9192
  • Abstract
    A 19-step synthesis of (±)-cribrostatin 4 (1) from readily available piperazine-2,5-dione derivative 6 is described. The synthesis features the concise construction of a pentacyclic framework, followed by the base-catalyzed epimerization of the C-1 stereo center of aldehyde (11). The results of cytotoxicity studies are also presented.
  • Keywords
    isoquinoline , Cytotoxicity , Total synthesis , marine natural product , Cribrostatin 4
  • Journal title
    Tetrahedron
  • Serial Year
    2011
  • Journal title
    Tetrahedron
  • Record number

    1103885

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1103885