Title of article
An Improved Synthesis of Pyridoxine via [2+2+2] Cyclization of Acetylenes and Nitriles
Author/Authors
Fischer، Christine نويسنده , , Gutnov، Andrey نويسنده , , Abaev، Vladimir نويسنده , , Redkin، Dmitry نويسنده , , Bonrath، Werner نويسنده , , Heller، Barbara نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
-1187
From page
1188
To page
0
Abstract
An improved synthesis of pyridoxine (vitamin B6) is reported. The key step involves the light-promoted [2+2+2] cyclization of 3,3-bissilyl-di-2propynyl ethers and acetonitrile in the presence of [cpCo(cod)] (1 mol%) as a catalyst. Convenient oxidation and iodination procedures are elaborated to transfer 3-silylpyridines into corresponding 3-hydroxy- and 3-iododerivatives.
Keywords
pyridines , Alkynes , nitriles , Cyclizations , vitamins
Journal title
Synlett
Serial Year
2005
Journal title
Synlett
Record number
110389
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