Title of article :
An Improved Synthesis of Pyridoxine via [2+2+2] Cyclization of Acetylenes and Nitriles
Author/Authors :
Fischer، Christine نويسنده , , Gutnov، Andrey نويسنده , , Abaev، Vladimir نويسنده , , Redkin، Dmitry نويسنده , , Bonrath، Werner نويسنده , , Heller، Barbara نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
An improved synthesis of pyridoxine (vitamin B6) is reported. The key step involves the light-promoted [2+2+2] cyclization of 3,3-bissilyl-di-2propynyl ethers and acetonitrile in the presence of [cpCo(cod)] (1 mol%) as a catalyst. Convenient oxidation and iodination procedures are elaborated to transfer 3-silylpyridines into corresponding 3-hydroxy- and 3-iododerivatives.
Keywords :
pyridines , Alkynes , nitriles , Cyclizations , vitamins
