Title of article
Base-catalyzed cyclization reaction of 2-chloroquinoline-3-carbonitriles and guanidine hydrochloride: a rapid synthesis of 2-amino-3H-pyrimido[4,5-b]quinolin-4-ones
Author/Authors
Atish Chandra، نويسنده , , Shraddha Upadhyay، نويسنده , , Bhawana Singh، نويسنده , , Neha Sharma، نويسنده , , Radhey M. Singh، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
6
From page
9219
To page
9224
Abstract
t-BuOK-catalyzed cyclization of 2-chloroquinoline-3-carbonitriles with guanidine hydrochloride provided simple and rapid synthesis of 2-amino-3H-pyrimido[4,5-b]quinolin-4-ones in very short reaction time with good yield. Other 1,3-binucleophiles are found to react at the same rate. This methodology could be extended with their 3-formyl and 3-ester derivatives for the synthesis of pyrimido annulated quinolines.
Keywords
Pyrimidoquinoline , 2-Chloroquinoline-3-carbonitrile , Base-catalyzed , Guanidine hydrochloride
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103890
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