Microwave-assisted chemoselective reaction: a divergent synthesis of pyrazolopyridine derivatives with different substituted patterns

A series of new functionalized pyrazolopyridine derivatives with different substituted patterns were synthesized via microwave-assisted multi-component divergent reactions of aldehydes, 5-aminopyrazoles, and cycloketones by controlling the reaction condition. The procedures are facile, avoiding time-consuming and costly syntheses, tedious work-up, and purifications of precursors as well as protection/deprotection of functional groups. This chemistry provides an efficient and promising synthetic strategy to construction of the pyrazolopyridine skeleton.