Title of article
An efficient one-pot multicomponent approach to 5-amino-7-aryl-8-nitrothiazolo[3,2-a]pyridines
Author/Authors
Cevher Altug، نويسنده , , Alan K. Burnett، نويسنده , , Esra Caner، نويسنده , , Yasar Durust، نويسنده , , Mark C. Elliott، نويسنده , , Roger P.J. Glanville، نويسنده , , Carol Guy، نويسنده , , Andrew D. Westwell، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
7
From page
9522
To page
9528
Abstract
A series of thiazolo[3,2-a]pyridines have been prepared using a multicomponent reaction between aromatic aldehydes, 2-nitromethylenethiazolidine and nitriles containing an active methylene group (malononitrile, ethyl 2-cyanoacetate and 2-phenylsulfonylacetonitrile) in the presence of Et3N under mild conditions with high yields. One of the compounds shows promising anticancer activity across a range of cancer cell lines.
Keywords
Heterocycles , thiazoline , nitrile , Knoevenagel reaction , Pyridine , Multicomponent reactions
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103926
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