One-pot synthesis of tetrahydrochromene derivatives catalyzed by lipase

An efficient and green one-pot synthesis route for tetrahydrochromene derivatives was developed. Lipase from Porcine pancreas (PPL) shows excellent catalytic activity and exerts good adaptability to different substrates in the reaction. All the reactions go smoothly and provide tetrahydrochromene derivatives with isolate yield up to 97% under room temperature. This lipase-catalyzed multistep conversion method has provided a new strategy to synthesize chromene derivatives and expanded the application of enzyme in organic synthesis.