Title of article
Syntheses and cytotoxicity of syringolin B-based proteasome inhibitors
Author/Authors
Tannya R. Ibarra-Rivera، نويسنده , , John Opoku-Ansah، نويسنده , , Sudhakar Ambadi، نويسنده , , André S. Bachmann، نويسنده , , Michael C. Pirrung، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
7
From page
9950
To page
9956
Abstract
The concise and modular total synthesis of the bacterial natural product and irreversible proteasome inhibitor syringolin B has been achieved. This synthesis has enabled the ready preparation of three diverse, structurally modified syringolin derivatives. The actions of these compounds in inhibiting the proliferation of neuroblastoma cell lines was evaluated, and significant enhancements in potency compared to the natural product were realized.
Keywords
Total synthesis , Drug discovery , Cancer , Lactam , Macrocycles
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103970
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