Title of article
A stereoselective total synthesis of (±)-tormesol
Author/Authors
Hyoungsu Kim، نويسنده , , Hoon Bae، نويسنده , , Sanghee Kim، نويسنده , , Deukjoon Kim، نويسنده , , Dongjoo Lee، نويسنده , , Robert S. Paton، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
9
From page
10017
To page
10025
Abstract
A general strategy for the synthesis of both trans/syn- and trans/anti-sphenolobane diterpenes has been developed, which utilizes an intramolecular ester enolate alkylation (IEEA) as a key step. A stereoselective total synthesis of (±)-tormesol (1), an unusual trans/syn-sphenolobane diterpene, was accomplished in 18 steps in 4.1% overall yield from readily available aldehyde 16.
Keywords
Intramolecular ester enolate alkylation , Tormesol , Hydroazulene , Cerium-promoted Grignard reaction
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103978
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