Title of article
Enantioselective access to (−)-indolizidines 167B, 209D, 239AB, 195B and (−)-monomorine from a common chiral synthon
Author/Authors
Chada Raji Reddy، نويسنده , , Bellamkonda Latha، نويسنده , , Nagavaram Narsimha Rao، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
7
From page
145
To page
151
Abstract
An enantioselective access to (−)-indolizidine alkaloids 167B, 209D, 239AB, 195B and (−)-monomorine from a new chiral synthon is described. The use of (S)-3-(Cbz-amino)-4-(tert-butyldimethylsilyloxy)butanal, obtained from l-aspartic acid, has provided efficient access of the indolizidine frame work through a Horner–Wadsworth–Emmons reaction and reductive cyclization as the key steps.
Keywords
Horner–Wadsworth–Emmonsreaction , Reductive cyclization , Indolizidine alkaloid , Chiral synthon
Journal title
Tetrahedron
Serial Year
2012
Journal title
Tetrahedron
Record number
1104024
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