Title of article
1,4-Dithiane-2,5-diol as an efficient synthon for a straightforward synthesis of functionalized tetrahydrothiophenes via sulfa-Michael/aldol-type reactions with electrophilic alkenes
Author/Authors
Nikla Baricordi، نويسنده , , Simonetta Benetti، نويسنده , , Valerio Bertolasi، نويسنده , , Carmela De Risi، نويسنده , , Gian P. Pollini، نويسنده , , Francesco Zamberlan، نويسنده , , Vinicio Zanirato، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
6
From page
208
To page
213
Abstract
‘One-pot’ tandem reactions of commercially available 1,4-dithiane-2,5-diol (the dimer of mercaptoacetaldehyde) with electrophilic alkenes resulted in the facile formation of substituted tetrahydrothiophene derivatives. Thus, sulfa-Michael/Henry and sulfa-Michael/aldol sequences provided polysubstituted tetrahydrothiophenes using in situ generated nitroalkenes and α,β-unsaturated carbonyl compounds as the electrophilic partners of mercaptoacetaldehyde dimer, respectively.
Keywords
Sulfa-Michael reactions , Tetrahydrothiophenes , sulfur heterocycles , tandem reactions
Journal title
Tetrahedron
Serial Year
2012
Journal title
Tetrahedron
Record number
1104033
Link To Document