Title of article
Enantioselective addition of terminal alkynes to N-(diphenylphosphinoyl)imines catalyzed by Zn–BINOL complexes
Author/Authors
Gonzalo Blay، نويسنده , , Eric Ceballos، نويسنده , , Alicia Monle?n، نويسنده , , José R. Pedro، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
7
From page
2128
To page
2134
Abstract
Chiral nonracemic N-(diphenylphosphinoyl)-protected propargylic amines have been prepared by addition of terminal alkynes to N-(diphenylphosphinoyl)aldimines in the presence of dimethylzinc and 3,3′-dibromo-BINOL as catalyst. The reaction works with a variety of aromatic and heteroaromatic aldimines and with different alkynes, providing the expected products in generally good yields and enantiomeric excesses (up to 96%).
Keywords
Alkynylation , C–C bond formation , Propargylic amines , Asymmetric catalysis , Nucleophilic addition
Journal title
Tetrahedron
Serial Year
2012
Journal title
Tetrahedron
Record number
1104262
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