Selective syntheses of novel highly functionalized β-aminocyclohexanecarboxylic acids

Highly functionalized β-aminocyclohexanecarboxylate regio- and stereoisomers were synthetized from racemic unsaturated bicyclic β-lactams via enzymatic resolution, selective transformation of the C–C double bond by stereoselective epoxidation, and regioselective oxirane ring opening with azide or cyanide as nucleophile.