Title of article :
Short and Efficient Synthesis of Cadiolide B
Author/Authors :
Boukouvalas، John نويسنده , , Pouliot، Martin نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
The first synthesis of cadiolide B has been achieved in 6 steps and 42% overall yield from 4-bromo-2(5H)-furanone. The pathway involves sequential, regiocontrolled introduction of the three furanone substituents by means of aldol reactions and Suzuki cross coupling.
Keywords :
total synthesis , lactones , aldol reaction , 2-furanolates , cross coupling
