Author/Authors :
Morteza Shiri، نويسنده , , Mohammad Ali Zolfigol، نويسنده , , Mahtab Pirveysian، نويسنده , , Roya Ayazi-Nasrabadi، نويسنده , , Hendrik G. Kruger، نويسنده , , Tricia Naicker، نويسنده , , Iraj Mohammadpoor-Baltork، نويسنده ,
Abstract :
Preparation of 2-(indol-3-yl)-3-nitriloquinolines via Friedländer quinoline synthesis using 3-cyanoacetylindoles possessing an α-methylene group and ortho-amino arylketones have been described. This reaction took place in PEG-400 as a green solvent and it is catalyzed with polyphosphoric acid (PPA) to give novel types of quinolines containing both indoles and cyano functions in one step under thermal and microwave conditions.
Keywords :
Quinolines , Indoles , Friedl?nder quinoline synthesis , Ethylene glycol
