New sesquiterpenes from the roots of Coriaria nepalensis

Six new trace sesquiterpenes, corialactones A–D (1–4), coriantone (5), corianol (6), together with nine known ones (7–15), were isolated from the roots of Coriaria nepalensis. The structures of 1–6 were elucidated through a combination of extensive NMR spectroscopic analysis, HRESIMS, CD, Rh2(OCOCF3)4-induced CD, Snatzkeʹs method, and X-ray crystallography. Compounds 2–4, and 6 possess characteristic structural units compared with the previously reported sesquiterpenes from this family. In vivo system, compounds 5, 6 and 10 showed anti-convulsant activity by 20%, 60%, and 20% at the dose of 5 mg/kg, respectively.