Title of article :
Practical one-pot preparation of ketones from aryl and alkyl bromides with aldehydes and DIH via Grignard reagents
Author/Authors :
Souya Dohi، نويسنده , , Katsuhiko Moriyama، نويسنده , , Hideo Togo، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Pages :
8
From page :
6557
To page :
6564
Abstract :
Various diaryl ketones, alkyl aryl ketones, and dialkyl ketones were efficiently prepared in good yields by the reactions of the Grignard reagents derived from aryl or alkyl bromides, followed by the reactions with aromatic or aliphatic aldehydes and the subsequent treatment with 1,3-diiodo-5,5-dimethylhydantoin and K2CO3, in a one-pot method. The same treatment of aromatic bromides bearing electron-withdrawing groups, such as ester, nitrile, ketone, and nitro groups with i-PrMgCl·LiCl or PhMgCl instead of Mg, also provided the corresponding diaryl and alkyl aryl ketones in good yields. The above methods are simple and practical transition-metal-free methods for the preparation of various diaryl ketones and alkyl aryl ketones bearing electron-rich aromatic groups and electron-deficient aromatic groups, as well as dialkyl ketones.
Journal title :
Tetrahedron
Serial Year :
2012
Journal title :
Tetrahedron
Record number :
1104785
Link To Document :
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