Synthesis of fluorinated N-aminoaziridines: access to new CF3-peptidomimetics

A series of fluorinated N-aminoaziridines have been synthesized by the PhI(OAc)2-mediated aziridination procedure. The reaction was carried out with various protected hydrazides and fluorinated alkenes. The reaction was extended to alkenes bearing an amino acid and the ring opening of the CF3–N-aminoaziridines has been investigated.