Title of article
Transferring oxygen isotopes to 1,2,4-benzotriazine 1-oxides forming the corresponding 1,4-dioxides by using the HOF·CH3CN complex
Author/Authors
Julia Gatenyo، نويسنده , , Kevin Johnson، نويسنده , , Anuruddha Rajapakse، نويسنده , , Kent S. Gates، نويسنده , , Shlomo Rozen، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
8942
To page
8944
Abstract
Heterocyclic benzotriazine N-oxides are an interesting class of experimental anticancer and antibacterial agents. Analogs with 18O incorporated into the N-oxide group may offer useful mechanistic tools. We describe the use of H218OF·CH3CN in a fast, readily executed and high-yielding preparation of 1,2,4-benzotriazine 1,4-dioxides containing an 18O-label at the 4-oxide position.
Keywords
H218O , Oxygen transfer , 18O isotope , Tirapazamine , HOF·CH3CN , F2/N2 , N-oxide
Journal title
Tetrahedron
Serial Year
2012
Journal title
Tetrahedron
Record number
1105067
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