Title of article
Synthesis on novel Tamoxifen derivatives
Author/Authors
Jullien Rey، نويسنده , , Haipeng Hu، نويسنده , , James P. Snyder، نويسنده , , Anthony G.M. Barrett، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
7
From page
9211
To page
9217
Abstract
The design and synthesis of derivatives of 4-hydroxy-Tamoxifen as potential antagonists of the nuclear receptor LRH-1 are described. Stereoselective McMurry coupling was used to generate the desired internal alkene and a novel method for the synthesis of tetrasubstituted cyclopropane analogues was also developed.
Keywords
Computer assisted drug design , Cyclopropanation , Tamoxifen , Antagonist
Journal title
Tetrahedron
Serial Year
2012
Journal title
Tetrahedron
Record number
1105097
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