Author/Authors :
Tsuyoshi Yamamoto، نويسنده , , Naoyuki Izumi، نويسنده , , Hideaki Ui، نويسنده , , Akito Sueki، نويسنده , , Rokuro Masuma، نويسنده , , Kenichi Nonaka، نويسنده , , Tomoyasu Hirose، نويسنده , , Toshiaki Sunazuka، نويسنده , , Takayuki Nagai، نويسنده , , Haruki Yamada، نويسنده , , Satoshi Omura، نويسنده , , Kazuro Shiomi، نويسنده ,
Abstract :
Wickerols A and B were produced by a fungus, Trichoderma atroviride FKI-3849. Wickerol A showed potent anti-influenza virus activity against strain A/PR/8/34 (H1N1), whereas wickerol B exhibited weaker impact. The anti-influenza virus spectrum between wickerols A and B was different. The cyclization mechanism of the wickerol carbon-skeleton was investigated by incorporation of 13C-labeled acetate. A pathway through the verticillyl cation was predicted.
Keywords :
Wickerol , Anti-influenza virus , diterpene , Trichoderma atroviride
