Title of article :
An Expeditious Synthesis of Nocardiolactone
Author/Authors :
Sun، Ya-Ping نويسنده , , Wu، Yikang نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
Nocardiolactone was synthesized by using a Crimmins asymmetric aldolization followed by a DMAP-mediated removal of the auxiliary with concurrent protection of the carboxylic group as a benzyl ester, activation of the (beta)-hydroxyl group as a mesylate, hydrogenolysis of the benzyl ester, and a novel DBU-mediated lactonization that converted the syn-configuration to the trans one.
Keywords :
asymmetric synthesis , chiral auxiliaries , lactones , ring contractions , total synthesis
