Title of article
An Expeditious Synthesis of Nocardiolactone
Author/Authors
Sun، Ya-Ping نويسنده , , Wu، Yikang نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
-1476
From page
1477
To page
0
Abstract
Nocardiolactone was synthesized by using a Crimmins asymmetric aldolization followed by a DMAP-mediated removal of the auxiliary with concurrent protection of the carboxylic group as a benzyl ester, activation of the (beta)-hydroxyl group as a mesylate, hydrogenolysis of the benzyl ester, and a novel DBU-mediated lactonization that converted the syn-configuration to the trans one.
Keywords
asymmetric synthesis , chiral auxiliaries , lactones , ring contractions , total synthesis
Journal title
Synlett
Serial Year
2005
Journal title
Synlett
Record number
110535
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