Title of article :
Asymmetric total synthesis of (−)-rasfonin
Author/Authors :
Rajib Bhuniya، نويسنده , , Samik Nanda، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
An efficient chemoenzymatic asymmetric synthesis of pyranone containing natural product (−)-rasfonin is presented here. Enantioselective enzymatic desymmetrization (EED) and a unique Gluconobacter oxydans mediated oxidative kinetic resolution (OKR) have been successfully employed to install three stereocenters (C6′, C7, and C9) of the target molecule. Stereoselective Achmatowicz reaction of a properly decorated furyl nucleus led to the core pyranone structure of rasfonin. At the late stage of the synthesis Negishi coupling has been used to complete the synthesis.
Journal title :
Tetrahedron
Journal title :
Tetrahedron