Author/Authors :
Zi-Ping Lin، نويسنده , , Fung Fuh Wong، نويسنده , , Yen-Bo Chen، نويسنده , , Yu-Cheng Lin، نويسنده , , Masayuki Kimura، نويسنده , , Kimiyoshi Kaneko، نويسنده , , Hiroyuki Takayama، نويسنده , , Jin Bin Wu، نويسنده , , Chun-Hung Lin، نويسنده , , Hui-Chang Lin، نويسنده ,
Abstract :
α-2-Deoxyulosides were synthesized in moderate to good yields by Michael addition of various O-nucleophiles to hex-1-en-3-ones in the presence of NaOH. These glycosyl additions were complete in 30 min at room temperature with high α-stereoselectivity in 53–92% yield. In addition, high α-stereoselectivity was also observed when S-nucleophiles were examined at 0 °C for 90 min.
Keywords :
?-2-Deoxy-uloside , Michael addition , Sodium hydroxide , Hex-1-en-3-one , 2-Deoxyglycoside
