Author/Authors :
Hsu-Ming Chung، نويسنده , , Jui-Hsin Su، نويسنده , , Tsong-Long Hwang، نويسنده , , Jan-Jung Li، نويسنده , , Jih-Jung Chen، نويسنده , , Yung-Husan Chen، نويسنده , , Yu-Chia Chang، نويسنده , , Yin-Di Su، نويسنده , , Yu-Hsin Chen، نويسنده , , Lee-Shing Fang، نويسنده , , Jyh-Horng Sheu، نويسنده , , Wei-Hsien Wang، نويسنده , , Ping-Jyun Sung، نويسنده ,
Abstract :
Three new clovane-related sesquiterpenoids, rumphellclovanes C–E (1–3), and a new natural clovane, clovan-2,9-dione (4), were isolated from a gorgonian coral Rumphella antipathies. The structures of clovanes 1–4 were elucidated by spectroscopic methods and by comparison of the spectral data with those of related analogues. Rumphellclovane C (1) was proven to be the first clovane-type sesquiterpenoid containing an ε-lactone moiety. A plausible biosynthetic pathway between clovanes 1 and 2 was proposed. Clovane 4 displayed significant inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
Keywords :
Rumphellclovane , Rumphella , Superoxide anion , elastase , Clovane
