Title of article
Total synthesis of the marine natural products lukianols A and B
Author/Authors
Kaoru Takamura، نويسنده , , Hisami Matsuo، نويسنده , , Ayana Tanaka، نويسنده , , Junji Tanaka، نويسنده , , Tsutomu Fukuda، نويسنده , , Fumito Ishibashi، نويسنده , , Masatomo Iwao، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
7
From page
2782
To page
2788
Abstract
Total synthesis of the pyrrolic marine natural products lukianols A (1) and B (2) has been achieved using N-benzenesulfonyl-3,4-dibromopyrrole (3) as a common starting material. The key synthetic strategy developed is the combined bromine-directed lithiation and palladium-catalyzed cross-coupling of 3 to produce 3,4-diarylpyrrol-2-carboxylates. Regioselective iodination of the phenolic intermediate 24 was thoroughly investigated for the synthesis of lukianol B.
Keywords
Lukianols A , Directed lithiation , Cross-coupling , B , Total synthesis , Pyrrole
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1105615
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