A novel route to synthesize lavendamycin analogues through an A3 coupling reaction

A convergent synthesis of lavendamycin analogues has been accomplished by using A3 coupling reaction between carboline aldehydes, anilines, and phenylacetylenes. Our approach features the use of the ionic liquids as an environmentally benign solvent medium and synthesis of lavendamycin analogues with diverse substitution pattern. Additionally, the formation of α-dihydropyrido-β-carboline was observed during the reaction of α-formyl-β-carboline, aniline, and ethylpropiolate.