Author/Authors :
Yan Zhang، نويسنده , , Xianjin Yang، نويسنده , , Frank” Tian Xie، نويسنده , , Guanlong Chen، نويسنده , , Wen-Hua Zhu، نويسنده , , Xiaoqi Zhang، نويسنده , , Xueyan Yang، نويسنده , , Xin-Yan Wu، نويسنده , , Xiao-Peng He، نويسنده , , Hao-Ming He، نويسنده ,
Abstract :
Structurally modified N-fluorobenzenesulfonimides (NFSIs) have been used to study the enantioselective fluorination of oxindoles in the presence of a bis-cinchona alkaloid, (DHQD)2PHAL, as the catalyst. We observe that the NFSI analogues bearing two tert-butyl groups at the para-position of the symmetric phenyl rings led to an enhanced enantioselectivity in most cases (up to 96% ee) compared with the unmodified NFSIs (less than 69% ee).
Keywords :
Oxindole , N-Fluorobenzenesulfonimides , Fluorination , Enantioselectivity
