Title of article
Chemoenzymatic synthesis of orthogonally protected (3R,4R)- and (3S,4S)-trans-3-amino-4-hydroxypyrrolidines
Author/Authors
Jes?s A. Rodr?guez-Rodr?guez، نويسنده , , F. Javier Quijada، نويسنده , , Rosario Brieva، نويسنده , , Francisca Rebolledo، نويسنده , , Vicente Gotor، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
6
From page
5407
To page
5412
Abstract
Several orthogonally protected racemic trans-3-amino-4-hydroxypyrrolidines have been easily prepared from N-Cbz-3,4-epoxypyrrolidine. Resolution of each racemic compound was accomplished by means of lipase-catalyzed aminolysis, transesterification or hydrolysis reactions. In most cases, the corresponding remaining substrates and the products were obtained with very high enantiomeric excesses.
Keywords
Hydrolysis , Lipase , Pyrrolidine , Transesterification , Vicinal amino alcohol
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1105920
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