Title of article
Enantioselective cyclization of enamide-ynes and application to the synthesis of the kopsifoline core
Author/Authors
Britton K. Corkey، نويسنده , , Stephen T. Heller، نويسنده , , Yi-Ming Wang، نويسنده , , F. Dean Toste، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
7
From page
5640
To page
5646
Abstract
We report the palladium-catalyzed enantioselective cyclization of 1,6-enamidynes to form spirocyclic ring systems. We applied this methodology to the concise synthesis of the skeletal core of the kopsifoline alkaloids.
Keywords
spirocyclization , natural product synthesis , Palladium catalysis , Electrophilic activation , Enantioselective synthesis
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1105950
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