Title of article :
Enantioselective cyclization of enamide-ynes and application to the synthesis of the kopsifoline core
Author/Authors :
Britton K. Corkey، نويسنده , , Stephen T. Heller، نويسنده , , Yi-Ming Wang، نويسنده , , F. Dean Toste، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
We report the palladium-catalyzed enantioselective cyclization of 1,6-enamidynes to form spirocyclic ring systems. We applied this methodology to the concise synthesis of the skeletal core of the kopsifoline alkaloids.
Keywords :
spirocyclization , natural product synthesis , Palladium catalysis , Electrophilic activation , Enantioselective synthesis
Journal title :
Tetrahedron
Journal title :
Tetrahedron
