Title of article
Nine new lycopodine-type alkaloids from Lycopodium japonicum Thunb
Author/Authors
Xiao-Jing Wang، نويسنده , , Li Li، نويسنده , , Yi-Kang Si، نويسنده , , Shishan Yu، نويسنده , , Shuanggang Ma، نويسنده , , Xiu-Qi Bao، نويسنده , , Dan Zhang، نويسنده , , Jing Qu، نويسنده , , Yunbao Liu، نويسنده , , Yong Li، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
7
From page
6234
To page
6240
Abstract
Nine new alkaloids (1–9) with lycopodine-related structures, i.e., 6α,8β-dihydroxylycopodine, 4α,8β-dihydroxylycopodine, alongside thirteen known compounds (10–22), were isolated from the club moss Lycopodium japonicum Thunb. The structures of the new alkaloids including their absolute configurations were elucidated by extensive spectroscopic analysis, CD method, and by comparison with known analogs. Six of the alkaloids isolated displayed moderate activities against lipopolysaccharide (LPS)-induced pro-inflammatory factors in BV2 macrophages with IC50 values of 4.23–49.03 μM.
Keywords
Lycopodium japonicum Thunb. , Alkaloid , Anti-inflammatory activity , Lycopodine
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1106023
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