Title of article
Enantioselective Michael addition reactions in water using a DNA-based catalyst
Author/Authors
Yinghao Li، نويسنده , , Changhao Wang، نويسنده , , Guoqing Jia، نويسنده , , Shengmei Lu، نويسنده , , Can Li، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
6
From page
6585
To page
6590
Abstract
Enantioselective Michael addition reactions of malononitrile and cyanoesters to α,β-unsaturated 2-acylimidazoles can be achieved in water using a DNA-based catalyst consisting of double-stranded DNA and copper(II) complex. Quantitative conversions and good enantioselectivities (up to 84% ee) are obtained for a wide range of substrates. The UV–vis absorption and circular dichroism (CD) indicate that the copper(II) complex may interact with salmon testes DNA via minor groove binding.
Keywords
Water , Asymmetric catalysis , Salmon testes DNA , Michael addition , Lewis acid
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1106066
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