Author/Authors :
Tsukasa Arai، نويسنده , , Yuta Toda، نويسنده , , Kiyotaka Kato، نويسنده , , Junichi Ueda ، Kensuke Miyamoto ، نويسنده , , Tsuyoshi Hasegawa، نويسنده , , Kosumi Yamada، نويسنده , , Junichi Ueda، نويسنده , , Koji Hasegawa، نويسنده , , Tsuyoshi Inoue، نويسنده , , Hideyuki Shigemori، نويسنده ,
Abstract :
A new sesquiterpene with an α-methylene-γ-lactone moiety, artabolide (1), and three known derivatives 2–4 were isolated from Artemisia absinthium. The structure of 1 was elucidated by 1D and 2D NMR analyses, and the absolute configuration was determined using the modified Mosherʹs method and X-ray crystal structural analysis. Approximately 2.5 μg/plant treatment of artabolide (1) exhibited ca. 50% inhibition of polar auxin transport in radish hypocotyls, while 2–4 showed no significant inhibitory activity. Therefore, these results support the importance of the α-methylene-γ-lactone moiety for the inhibition of polar auxin transport.
Keywords :
?-Methylene-?-lactone , Polar auxin transport inhibitor , Modified Mosherיs method , Artabolide , X-ray crystal structure analysis
