Title of article :
Biomimetic synthesis of an antitumour indole sesquiterpene alkaloid, 12-epi-ent-pentacyclindole
Author/Authors :
Isidro S. Marcos، نويسنده , , Rosalina F. Moro، نويسنده , , Isabel Costales، نويسنده , , Pilar Basabe، نويسنده , , David Diez، نويسنده , , Faustino Mollinedo، نويسنده , , Julio G. Urones، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
Biomimetic synthesis of 12-epi-ent-pentacyclindole 7, using as key step the cyclization of 12-epi-ent-polyalthenol acetate has been carried out. This way, the structure and absolute configuration of the natural product pentacyclindole 1 has been confirmed. The synthesized indole sesquiterpenes 7, 11 and 12 show cellular proliferation inhibition of a number of human leukaemic and solid tumour cell lines.
Keywords :
Pentacyclindole , Polyalthenol , Antitumour , ent-halimic acid , Indole sesquiterpenes
Journal title :
Tetrahedron
Journal title :
Tetrahedron
