Author/Authors :
Yuji Kurogome، نويسنده , , Masaya Kogiso، نويسنده , , Kok Kong Looi، نويسنده , , Yasunao Hattori، نويسنده , , Hiroyuki Konno، نويسنده , , Mitsuru Hirota، نويسنده , , Hidefumi Makabe، نويسنده ,
Abstract :
The aminopalladation of amino allylic alcohol using Cl2Pd(MeCN)2 in CH2Cl2 gave the 2,6-disubstituted piperidine with excellent diastereoselectivity. This compound was successfully converted into (+)-azimine (1) using cross-metathesis and Shiina macrolactonization.
Keywords :
Aminopalladation , Alkaloids , piperidine , Natural product
